UGT2B7

UGT2B7
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2O6L
Identifiers
Aliases	UGT2B7, UDPGT 2B9, UDPGT2B7, UDPGTH2, UGT2B9, UDP glucuronosyltransferase family 2 member B7
External IDs	MGI: 3576100 HomoloGene: 128251 GeneCards: UGT2B7
Genetically Related Diseases
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Gene ontology Molecular function • transferase activity, transferring glycosyl groups • transferase activity • glucuronosyltransferase activity • retinoic acid binding • transferase activity, transferring hexosyl groups Cellular component • integral component of membrane • organelle membrane • extracellular exosome • endoplasmic reticulum membrane • membrane • intracellular membrane-bounded organelle • endoplasmic reticulum Biological process • steroid metabolic process • metabolic process • cellular glucuronidation • androgen metabolic process • lipid metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7364	243085
Ensembl	ENSG00000171234	ENSMUSG00000035811
UniProt	P16662	n/a
RefSeq (mRNA)	NM_001074 NM_001330719	NM_172881
RefSeq (protein)	NP_001065 NP_001317648	n/a
Location (UCSC)	Chr 4: 69.05 – 69.11 Mb	Chr 5: 87 – 87.01 Mb
PubMed search

2O6L

7364

243085

ENSG00000171234

ENSMUSG00000035811

P16662

n/a

NM_001074
NM_001330719

NM_172881

NP_001065
NP_001317648

n/a

UGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. In humans, UDP-Glucuronosyltransferase-2B7 is encoded by the UGT2B7 gene.

The UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B7 has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites.

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