WT1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1XF7, 2JP9, 2JPA, 2PRT, 3HPJ, 3MYJ, 4R2E, 4R2P, 4R2Q, 4R2R, 4R2S, 4WUU

Identifiers

Aliases

WT1, AEWS-GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor 1

External IDs

MGI: 98968 HomoloGene: 11536 GeneCards: WT1

Gene ontology
Molecular function	• sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • C2H2 zinc finger domain binding • metal ion binding • protein binding • RNA binding • nucleic acid binding • transcription regulatory region DNA binding • double-stranded methylated DNA binding • hemi-methylated DNA-binding
Cellular component	• cytoplasm • nuclear speck • nucleoplasm • nucleolus • nucleus • cytosol
Biological process	• germ cell development • adrenal cortex formation • ureteric bud development • negative regulation of translation • male gonad development • male genitalia development • regulation of transcription, DNA-templated • epithelial cell differentiation • glomerular basement membrane development • diaphragm development • kidney development • regulation of transcription from RNA polymerase II promoter • posterior mesonephric tubule development • visceral serous pericardium development • metanephric epithelium development • negative regulation of apoptotic process • glomerulus development • negative regulation of transcription from RNA polymerase II promoter • adrenal gland development • transcription, DNA-templated • positive regulation of metanephric ureteric bud development • vasculogenesis • positive regulation of transcription, DNA-templated • positive regulation of heart growth • heart development • negative regulation of female gonad development • branching involved in ureteric bud morphogenesis • regulation of animal organ formation • sex determination • negative regulation of cell growth • RNA splicing • cardiac muscle cell fate commitment • tissue development • positive regulation of apoptotic process • camera-type eye development • metanephric S-shaped body morphogenesis • thorax and anterior abdomen determination • negative regulation of transcription, DNA-templated • gonad development • metanephric mesenchyme development • cellular response to gonadotropin stimulus • positive regulation of male gonad development • cellular response to cAMP • negative regulation of cell proliferation • mesenchymal to epithelial transition • negative regulation of metanephric glomerular mesangial cell proliferation • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • glomerular visceral epithelial cell differentiation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


7490


22431

Ensembl


ENSG00000184937


ENSMUSG00000016458

UniProt


P19544 Q6PI38


P22561

RefSeq (mRNA)

NM_024426 NM_000378 NM_001198551 NM_001198552 NM_024424
NM_024425


NM_144783

RefSeq (protein)

NP_000369 NP_001185480 NP_001185481 NP_077742 NP_077744
NP_000369.3 NP_001185480.1 NP_001185481.1 NP_077742.2 NP_077744.3


n/a

Location (UCSC)

Chr 11: 32.39 – 32.44 Mb

Chr 2: 105.13 – 105.17 Mb

PubMed search

WT1

Identifiers

Symbol

WT1

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

1XF7, 2JP9, 2JPA, 2PRT, 3HPJ, 3MYJ, 4R2E, 4R2P, 4R2Q, 4R2R, 4R2S, 4WUU

NP_000369.3
NP_001185480.1
NP_001185481.1
NP_077742.2
NP_077744.3

...
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