Y box binding protein 1

YBX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H95
Identifiers
Aliases	YBX1, BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1, CBF-A, EFI-A, Y-box binding protein 1
External IDs	MGI: 99146 HomoloGene: 88707 GeneCards: YBX1
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • RNA binding • nucleic acid binding • GTPase binding • double-stranded DNA binding • single-stranded DNA binding • chromatin binding Cellular component • cytoplasm • CRD-mediated mRNA stability complex • nuclear membrane • intracellular membrane-bounded organelle • U12-type spliceosomal complex • intracellular ribonucleoprotein complex • nucleoplasm • extracellular region • cytoplasmic stress granule • extracellular exosome • nucleus • histone pre-mRNA 3'end processing complex • cytosol Biological process • CRD-mediated mRNA stabilization • mRNA splicing, via spliceosome • regulation of transcription, DNA-templated • mRNA processing • transcription from RNA polymerase II promoter • protein localization to cytoplasmic stress granule • transcription, DNA-templated • positive regulation of cell division • positive regulation of transcription from RNA polymerase II promoter • in utero embryonic development • RNA splicing • negative regulation of striated muscle cell differentiation • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4904	22608
Ensembl	ENSG00000065978	ENSMUSG00000028639
UniProt	P67809	P62960
RefSeq (mRNA)	NM_004559	NM_011732
RefSeq (protein)	NP_004550	NP_035862
Location (UCSC)	Chr 1: 42.68 – 42.7 Mb	Chr 4: 119.28 – 119.29 Mb
PubMed search

1H95

4904

22608

ENSG00000065978

ENSMUSG00000028639

P67809

P62960

NM_004559

NM_011732

NP_004550

NP_035862

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.

YBX1 is a potential drug target in cancer therapy. YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy. Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses

Y box binding protein 1 has been shown to interact with:

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

...
Wikipedia