Zalospirone

Zalospirone

Clinical data
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Pharmacokinetic data
Biological half-life	1-4 hours
Identifiers
IUPAC name (3aα,4α,4aβ,6aβ,7α,7aα)-Hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-etheno-1H-cyclobut[f]isoindole-1,3(2H)-dione
CAS Number	114298-18-9
PubChem CID	163925
IUPHAR/BPS	58
ChemSpider	143768
UNII	0449O95Z1J
Chemical and physical data
Formula	C24H29N5O2
Molar mass	419.519 g/mol
3D model (Jmol)	Interactive image
SMILES O=C1N(C(=O)[C@@H]4[C@H]1[C@@H]2\C=C/[C@H]4[C@H]3\C=C/[C@@H]23)CCCCN6CCN(c5ncccn5)CC6
InChI InChI=1S/C24H29N5O2/c30-22-20-18-6-7-19(17-5-4-16(17)18)21(20)23(31)29(22)11-2-1-10-27-12-14-28(15-13-27)24-25-8-3-9-26-24/h3-9,16-21H,1-2,10-15H2/t16-,17+,18-,19+,20-,21+ Key:AERLHOTUXIJQFV-RCPZPFRWSA-N

Zalospirone (WY-47,846) is a selective 5-HT_1A partial agonist of the azapirone chemical class. It was found to be effective in the treatment of anxiety and depression in clinical trials, but a high proportion of subjects dropped out due to side effects and development was subsequently never completed.