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5-HT2A receptor

HTR2A
5ht2a.jpg
Identifiers
Aliases HTR2A, 5-HT2A, HTR2, 5-hydroxytryptamine receptor 2A
External IDs OMIM: 182135 MGI: 109521 HomoloGene: 68073 GeneCards: HTR2A
Targeted by Drug
LP-12, LP-44, 5-carboxamidotryptamine, pathogen, 5-methoxytryptamine, (+/-)-8-hydroxy-2-(di-N-propylamino)tetralin, AL-37350A, α-methyl-5-HT, aripiprazole, brl-15572, brolamfetamine, BW723C86, cabergoline, cgs 12066b-parent, 4-iodo-2,5-dimethoxyphenylisopropylamine, donitriptan, gr-127935, lorcaserin, lysergide, methylergonovine, mk-212, Org 12962, ORG-37684, pergolide, pindolol, quetiapine, quinpirole, quipazine, ru-24969, sb-216641, 1-(3-trifluoromethylphenyl)piperazine, tryptamine, VER-3323, bromocriptine, ergotamine, m-chlorophenylpiperazine, lisuride, terguride, agomelatine, apomorphine, blonanserin, bufotenine, (+)-butaclamol, cyamemazine, duloxetine, flibanserin, fluphenazine, fluspirilene, glemanserin, haloperidol, ketanserin, L-741,626, LY215840, mesoridazine, mesulergine, metergoline, metitepine, methysergide, mianserin, mirtazapine, molindone, nefazodone, olanzapine, perphenazine, pimozide, pipamperone, ritanserin, roxindole, RS-102221, rs-127445, sarpogrelate, sb-206553, SB 242084, SB 243213, SDZ SER-082, sertindole, spiperone, spiramide, thioridazine, thiothixene, trazodone, trifluoperazine, volinanserin, vortioxetine, xanomeline, ziprasidone, zotepine, chlorpromazine, clozapine, loxapine, pimavanserin, risperidone
RNA expression pattern
PBB GE HTR2A 207135 at tn.png

PBB GE HTR2A 211616 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001165947
NM_000621

NM_172812

RefSeq (protein)

NP_000612
NP_001159419

NP_766400.1
NP_766400

Location (UCSC) Chr 13: 46.83 – 46.9 Mb Chr 14: 74.64 – 74.71 Mb
PubMed search

NM_001165947
NM_000621

NM_172812

NP_000612
NP_001159419

NP_766400.1
NP_766400

The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was first noted for its importance as a target of serotonergic psychedelic drugs such as LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.


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Wikipedia

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