RS-127445

RS-127445

Identifiers
IUPAC name 4-(4-fluoro-1-naphthyl)-6-isopropylpyrimidin-2-amine
Synonyms	RS-127,445
CAS Number	199864-87-4
PubChem CID	196968
IUPHAR/BPS	188
ChemSpider	170590
UNII	0JAU3P8OBM
ChEMBL	CHEMBL473186
Chemical and physical data
Formula	C17H16FN3
Molar mass	281.327 g/mol
3D model (Jmol)	Interactive image
SMILES Nc3nc(C(C)C)cc(n3)-c(cc2)c1ccccc1c2F
InChI InChI=1S/C17H16FN3/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13/h3-10H,1-2H3,(H2,19,20,21) Key:ZZZQXCUPAJFVBN-UHFFFAOYSA-N

RS-127445 is a drug which acts as a potent and selective antagonist at the serotonin 5-HT_2B receptor, with around 1000x selectivity over the closely related 5-HT_2A and 5-HT_2C receptors. The role of the 5-HT_2B receptor in the body is still poorly understood, and RS-127445 has been a useful tool in unravelling the function of the various systems in which this receptor is expressed.