Ergoline

Ergoline

Clinical data
ATC code	none
Identifiers
IUPAC name (6aR)-4,6,6a,7,8,9,10,10a-Octahydroindolo[4,3-fg]quinoline
CAS Number	478-88-6 Y
PubChem (CID)	6857537
ChemSpider	5256873 Y
ChEBI	CHEBI:38484 Y
Chemical and physical data
Formula	C14H16N2
Molar mass	212.29g/mol
3D model (Jmol)	Interactive image
SMILES c2c4c1c(cccc1n2)[C@@H]3[C@H](NCCC3)C4
InChI InChI=1S/C14H16N2/c1-3-11-10-4-2-6-15-13(10)7-9-8-16-12(5-1)14(9)11/h1,3,5,8,10,13,15-16H,2,4,6-7H2/t10-,13-/m1/s1 Y Key:RHGUXDUPXYFCTE-ZWNOBZJWSA-N Y

Ergoline is a chemical compound whose structural skeleton is contained in a diverse range of alkaloids. Ergoline derivatives are used clinically for the purpose of vasoconstriction (5-HT₁ receptor agonists—ergotamine) and in the treatment and alleviation of migraines (used with caffeine) and Parkinson's disease. Some ergoline alkaloids found in ergot fungi are implicated in the condition ergotism, which causes convulsive and gangrenous symptoms. Others are psychedelic substances, including LSD and some alkaloids in Argyreia nervosa, Ipomoea tricolor and related species.

In addition to the naturally occurring ergonovine (used as an ) and ergotamine (a vasoconstrictor used to control migraine), synthetic derivatives of importance are the oxytocic methergine, the anti-migraine drugs dihydroergotamine and methysergide, hydergine (a mixture of dihydroergotoxine mesylates, INN: ergoline mesylates), and bromocriptine, used for numerous purposes including treatment of Parkinson's disease. Newer synthetic ergolines used for Parkinson's disease include pergolide and lisuride.