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Methergine

Methylergometrine
Methylergometrin.svg
Clinical data
Trade names Methergine
AHFS/Drugs.com International Drug Names
MedlinePlus a601077
Pregnancy
category
  • Contraindicated
Routes of
administration
Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolism Liver
Biological half-life 30–120 min
Excretion Mostly bile
Identifiers
Synonyms Methylergobasine
Methylergobrevin
Methylergonovine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
ECHA InfoCard 100.003.661
Chemical and physical data
Formula C20H25N3O2
Molar mass 339.432 g/mol
3D model (Jmol)
Melting point 172 °C (342 °F)
Solubility in water insoluble mg/mL (20 °C)
 NYesY (what is this?)  

Methylergometrine (also called methylergonovine, methylergobasin, and D-lysergic acid 1-butanolamide) is a synthetic analogue of ergonovine, a psychedelic alkaloid found in ergot, and many species of morning glory. It is a member of the ergoline family and chemically similar to LSD, ergine, ergometrine, and lysergic acid. Due to its properties, it has a medical use in obstetrics. According to Jonathan Ott, methylergonovine has LSD-like actions above 2 milligrams, due to its agonistic action at the 5HT2A-mGlu2 receptor protomers. Clinical efficacy occurs around 200 µg, ten times lower than the hallucinogenic threshold.

Methylergometrine maleate is marketed under the trade name Methergine.

Methylergometrine is a smooth muscle constrictor that mostly acts on the uterus. It is most commonly used to prevent or control excessive bleeding following childbirth and spontaneous or elective abortion, and also to aid in expulsion of retained products of conception after a missed abortion (miscarriage in which all or part of the fetus remains in the uterus) and to help deliver the placenta after childbirth. It is available as tablets or injection (IM or IV) or in liquid form to be taken orally.


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