IFT20

IFT20
Identifiers
Aliases	IFT20, intraflagellar transport 20
External IDs	MGI: 1915585 HomoloGene: 49559 GeneCards: IFT20
Gene location (Human) Chr. Chromosome 17 (human) Band No data available Start 28,328,325 bp End 28,335,489 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band No data available Start 78,536,361 bp End 78,541,737 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • opsin binding • Rab GTPase binding Cellular component • cis-Golgi network • Golgi membrane • centriole • dendrite terminus • ciliary base • ciliary basal body • motile cilium • cytoplasm • photoreceptor connecting cilium • cytoskeleton • cell projection • ciliary tip • extracellular exosome • photoreceptor outer segment • centrosome • stereocilium • microvillus • intraciliary transport particle B • Golgi apparatus • kinociliary basal body • cilium Biological process • smoothened signaling pathway • cell projection organization • neurogenesis • neural precursor cell proliferation • photoreceptor cell outer segment organization • cardiac muscle cell differentiation • kidney development • protein localization to Golgi apparatus • opsin transport • regulation of canonical Wnt signaling pathway • visual learning • regulation of autophagosome assembly • regulation of cilium assembly • establishment of planar polarity • inner ear receptor stereocilium organization • protein localization to cilium • centrosome localization • cochlea development • intraciliary transport • intraciliary transport involved in cilium assembly • cilium morphogenesis • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90410	55978
Ensembl	ENSG00000109083	ENSMUSG00000001105
UniProt	Q8IY31	Q61025
RefSeq (mRNA)	NM_174887 NM_001267774 NM_001267775 NM_001267776 NM_001267777 NM_001267778	NM_018854
RefSeq (protein)	NP_001254703 NP_001254704 NP_001254705 NP_001254706 NP_001254707 NP_777547	NP_061342
Location (UCSC)	Chr 17: 28.33 – 28.34 Mb	Chr 17: 78.54 – 78.54 Mb
PubMed search

90410

55978

ENSG00000109083

ENSMUSG00000001105

Q8IY31

Q61025

NM_001267778

NM_018854

NP_777547

NP_061342

Intraflagellar transport protein 20 homolog is a protein that in humans is encoded by the IFT20 gene. The gene is composed of 6 exons and is located on human chromosome 17p11.1. This gene is expressed in human brain, lung, kidney and pancreas, and lower expression were also detected in human placenta, liver, thymus, prostate and testis.

Intraflagellar transport (IFT), in which molecular motors and IFT particle proteins participate, is very important in assembling and maintaining many cilia/flagella, such as the motile cilia that drive the swimming of cells and embryos, the nodal cilia that generate left-right asymmetry in vertebrate embryos, and the sensory cilia that detect sensory stimuli in some animals. IFT20 subunit of the particle is localized to the Golgi complex in addition to the basal body and cilia where all previous IFT particle proteins had been found. In living cells, fluorescently tagged IFT20 is highly dynamic and moves between the Golgi complex and the cilium as well as along ciliary microtubules. IFT20 has been shown to interact with SPEF2 in the testis, and plays a role in sperm motility.

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Wikipedia