SPEF2

SPEF2
Identifiers
Aliases	SPEF2, CT122, KPL2, sperm flagellar 2
External IDs	MGI: 2443727 HomoloGene: 23371 GeneCards: SPEF2
Gene location (Human) Chr. Chromosome 5 (human) Band No data available Start 35,617,844 bp End 35,814,611 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band No data available Start 9,578,193 bp End 9,748,868 bp
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79925	320277
Ensembl	ENSG00000152582	ENSMUSG00000072663
UniProt	Q9C093	Q8C9J3
RefSeq (mRNA)	NM_024867 NM_144722	NM_177123 NM_001305042 NM_001305044
RefSeq (protein)	NP_079143 NP_653323	NP_001291971 NP_001291973 NP_796097
Location (UCSC)	Chr 5: 35.62 – 35.81 Mb	Chr 5: 9.58 – 9.75 Mb
PubMed search

79925

320277

ENSG00000152582

ENSMUSG00000072663

Q9C093

Q8C9J3

NM_024867
NM_144722

NM_177123
NM_001305042
NM_001305044

NP_079143
NP_653323

NP_001291971
NP_001291973
NP_796097

Sperm flagellar protein 2 is a protein that in humans is encoded by the SPEF2 gene.

SPEF2 plays an important role in spermatogenesis and flagellar assembly. SPEF2 is expressed in all ciliated cells and is required for cilia function. Sperm contain cilia, and a mutation in the SPEF2 gene can cause male infertility due to immobile sperm. In a pig animal model, a SPEF2 mutation affects the sperm tail development. And a loss of function mutation in SPEF2 in mice causes the big giant head phenotype. SPEF2 mRNA and protein products are localized in germ and sertoli cells. Within these cells, SPEF2 is localized in the golgi complex, manchette, basal body and mid piece of the sperm tail. SPEF2 has been shown to interact with the intracellular transport protein IFT20 in the testis.

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Wikipedia