Rauwolscine

Rauwolscine

Clinical data
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 17α-hydroxy-20α-yohimban-16β-carboxylic acid methyl ester
CAS Number	131-03-3 N
PubChem CID	643606
IUPHAR/BPS	136
ChemSpider	558737 Y
ChEBI	CHEBI:48562 Y
ChEMBL	CHEMBL10347 Y
ECHA InfoCard	100.004.553
Chemical and physical data
Formula	C21H26N2O3
Molar mass	354.44 g/mol
InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1 Y Key:BLGXFZZNTVWLAY-DIRVCLHFSA-N Y
NY (what is this?)

Rauwolscine, also known as isoyohimbine, α-yohimbine, and corynanthidine, is an alkaloid found in various species within the genera Rauwolfia and Pausinystalia (formerly known as Corynanthe). It is a stereoisomer of yohimbine. Rauwolscine is a central nervous system stimulant, a local anesthetic and a vague aphrodisiac.

Rauwolscine acts predominantly as a α₂-adrenergic receptor antagonist. It has also been shown to function as a 5-HT_1A receptor partial agonist and 5-HT_2A and 5-HT_2B receptor antagonist.