YM-348

YM-348

Identifiers
IUPAC name (2S)-​1-​(7-​ethyl-​1H-​furo[2,3-g]indazol-​1-​yl)propan-​2-​amine
CAS Number	372163-84-3
PubChem CID	3045225
IUPHAR/BPS	230
ChemSpider	2308001
Chemical and physical data
Formula	C14H17N3O
Molar mass	243.31 g·mol−1
3D model (Jmol)	Interactive image
SMILES n3cc2ccc1oc(cc1c2n3C[C@@H](N)C)CC
InChI InChI=1S/C14H17N3O/c1-3-11-6-12-13(18-11)5-4-10-7-16-17(14(10)12)8-9(2)15/h4-7,9H,3,8,15H2,1-2H3/t9-/m0/s1 Key:QLOOWOVVZLBYHU-VIFPVBQESA-N

YM-348 is an indazole derivative drug which acts as a potent and selective 5-HT_2C receptor agonist, with an EC₅₀ of 1nM and 15x selectivity over 5-HT_2A, although it only has moderate selectivity of 3x over the closely related 5-HT_2B receptor. It has thermogenic and anorectic effects in animal studies, making it potentially useful for the treatment of obesity.